Abstract

Bisphenol-A is a plastic constituent, known as an endocrine disruptor, has become ubiquitous in the environment due to its presence in various products such as food and beverage packaging. This study investigated both acute and sub-lethal effects of Bisphenol-A on some haematological and biochemical indices of Clarias gariepinus fingerlings (mean weight, 8.0 ± 0.9g and Standard length, 5.0 ± 0.3cm), exposed to varying concentrations (0, 3, 5, 8, 10, 12mg/l) of bisphenol-A exposed for 96 hours and 60 days in plastic aquaria of 20L capacity, to determine both acute and sublethal toxicity respectively in static bioassay. Haematologically, the acute and sub-lethal exposures of C. gariepinus to BPA showed significant changes in levels of anaemia and haemodilution with packed cell volume values (19.67±0.33 and 30.00±0.58), while biochemical indices also showed significant changes in levels of induced hyperproteinaemia with total protein values (1.70±0.10 and 1.83±0.09) in the highest concentrations of both acute and sub lethal toxicity. Further research should be carried out to investigate the effects and bioaccumulation of this chemical on the muscle, brain and gonads of the fish.